1 Characterization of Invasive Group B Streptococcus 1 from the Greater Toronto Area, Canada 2 3
Why this work is in the frame
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Bibliographic record
Abstract
2 Abstract 20 We determined the capsular polysaccharide (CPS) type of 600 group B Streptococcus (GBS, also known 21 as Streptococcus agalactiae) strains recovered from patients with invasive infections in the Greater 22 Toronto Area, Canada, between 2009 and 2012. GBS strains of CPS type III were the most prevalent 23 among infants (44 % in early-onset disease, 75 % in late-onset disease), while type V strains were most 24 frequently isolated from adult patients (26 % in patients 19 years and older). We next investigated the 25 presence in our collection of GBS strains belonging to the hypervirulent multilocus sequence typing 26 clonal complex (CC)17. We used a PCR test described as specific for detection of CC17 strains which 27 targets the gene encoding the major virulence factor HvgA. We identified 91 hvgA-positive strains; of 28 them 88 were CPS type III, 2 were CPS type IV and 1 was CPS type V. Using whole genome sequencing 29 we show that the two hvgA-positive, CPS type IV strains are CC17 strains which underwent capsular 30 switching. However, sequence analysis revealed that the hvgA-positive, CPS type V strain does not 31
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it