Bibliographic record
Abstract
The mold Aspergillus fumigatus spreads through dispersion of its asexual spores, called conidia. When inhaled, these conidia are efficiently eliminated by innate immune defenses. But, in immunocompromised patients, conidia escape killing to germinate into hyphae which invade host cells and proliferate in blood vessels, often disseminating to other organs. lnvasive aspergillosis (lA) occurs in up to 15 % of Canadian patients with acute leukemia or undergoing allogenic stem cell transplantation, and the mortality rate of IA remains greater than 50%, despite the use of new antifungal agents. Novel approaches to modify the natural history of this illness are urgently needed. A fumigatus is an opportunistic pathogen with relatively low intrinsic virulence. As a result the growth rate of the organism plays a crucial role in its ability to cause disease, and strains with reductions in hyphal growth rate exhibit reduced or no virulence. Efficient hyphal growth is favored by the fact that during invasive aspergillosis there is no conidiation allowing the organism to direct its energy towards vegetative growth. Conversely, work from our group and others has demonstrated
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.302 | 0.153 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".