RESEARCH ARTICLE c i n Background previously reported that mild excitotoxicity produced by
Bibliographic record
Abstract
Charlottetown, PEI, CanadaDomoic acid (DOM) is an AMPA/kainate receptor ligand that elicits a very rapid and potent neurotoxic response, and as such, has been used as a reliable re-search tool to investigate excitotoxic damage in vivo [1-4] and in vitro [5-7]. The hippocampus, among other brain regions, has been identified as a specific target site having high sensitivity to DOM-induced toxicity [8,9] and, at lower doses, to DOM-induced structural plasti-city relevant to temporal lobe epilepsy [10,11]. We have low concentrations of DOM was reversible and accom-panied by a corresponding increase in the baseline rate of neurogenesis in organotypic hippocampal slice cul-tures (OHSC) [7]. However, the intracellular mecha-nisms responsible for cell proliferation and neurogenesis after transient excitotoxic insult remain unclear. BDNF is a member of the neurotrophin family that plays important roles in many developmentally regulated processes, such as cell survival, differentiation and syn-aptic plasticity of neurons as well as neurogenesis. Some studies reveal that different forms of excitatory cellular * Correspondence:
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.098 | 0.027 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".