Reason for posting: WinRho is a human
Bibliographic record
Abstract
blood product, Rho(D) immune globu-lin, widely used to treat immune throm-bocytopenic purpura (ITP) and to pre-vent Rh alloimmunization in pregnant women who are Rh-negative. Recently, however, a case series1 described 6 pa-tients with ITP who were given WinRho who subsequently experienced severe hemolysis and disseminated intravas-cular coagulation (DIC); 5 of them died. The manufacturer, Cangene, has since issued “Dear Health Care Professional” letters in both Canada and the United States that warn of 9 international re-ports of this serious adverse effect.2 The drug: WinRho is a gamma globu-lin fraction of plasma containing anti-bodies to Rho(D) derived from blood donors. Donated plasma is stringently screened for known pathogens and then filtered to further reduce the risk of transmission of viruses such as hepati-tis B and C, HIV and parvovirus. WinRho is routinely given to Rh-negative women in their third trimester of pregnancy (28 weeks), postpartum (within 72 h) and after possible expo-sure to Rh-positive blood after preg-nancy termination, amniocentesis or abdominal trauma, to prevent maternal Rh-antibody formation and hemolytic disease of the newborn in future preg-nancies. WinRho is also used to treat ITP, an autoimmune disorder of in-creased splenic platelet destruction. Pregnant women are treated with 120–300 μg of WinRho, administered intravenously or intramuscularly. Pa-tients with ITP are given a much higher dose, generally 25–50 μg/kg intraven-ously. Common adverse effects, which often occur within minutes to days after the infusion, include headache, chills and fever, back pain and shaking. Seri-ous but rare adverse effects have includ-ed acute respiratory distress syndrome, acute renal insufficiency, acute anemia and hemoglobinuria.3 The recent post-marketing case reports add DIC as ano-ther rare but potentially serious adverse effect, which likely starts as hemoglob-inemia and hemoglobinuria. The 6 cases1 reported in the fall of 2005 were all submitted to the US Food
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.011 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.009 | 0.006 |
| Insufficient payload (model declined to judge) | 0.217 | 0.100 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".