RESEARCH Interference with protease
Bibliographic record
Abstract
Winnipeg, MB R3E 3P5, CanadaHemorrhage in the periventricular germinal tissue of developing brain (often called germinal matrix or peri-ventricular hemorrhage, PVH) is a major complication of preterm birth before 32 weeks gestational age [1]. PVH is associated with suppressed proliferation of the periventricular germinal cell populations in human in-fants [2]. The same suppression occurs in an experimen-tal mouse model [3]. It is important to understand this brain development and contribute to the neurological complications suffered by premature infants [4]. Blood injections have been shown to damage immature mouse brain; much of the effect seems to be attributable to the plasma proteins thrombin and plasmin [5,6]. Using cul-tured rat subventricular zone (SVZ) cells and oligo-dendrocyte precursor cells (OPC) we showed that blood plasma and blood serum, as well as purified thrombin, plasmin, and kallikrein had similar toxic effects on cell proliferation, migration, and differentiation [7]. Prothrombin is a serine protease contained in blood * Correspondence:
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.063 | 0.022 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".