Case Report Cronkhite-Canada Syndrome
Bibliographic record
Abstract
Cronkhite-Canada syndrome is one of the rare causes of multiple polyposis, characterised by generalised gastrointestinal polyposis, cutaneous hyperpigmentation, alopecia, and nail dystrophy. ' Although Cronkhite and Canada described it for the first time in 1955, little is known about its aetiology and the prognosis remains poor. We describe a case of Cronkhite-Canada syndrome in a 79-year-old Japanese man, which illustrates the typical features of the condition. CASE REPORT A 79 year old man presented with a history of weight loss of ten kilogrlms over a period of 2 months, associated with diminished taste and watery diarrhoea (4-5 times per day). He had pigmentation of the skin, especially on the hands, as well as dystrophic nail changes and alopecia with loss of8scalp and facial hair. Barium enema showed an unusual polypoid appearance throughout the colon with relative sparing of the ascending colon and caecum (figure 1). Colonoscopy revealed numerous polypoid lesions of the colonic and rectal mucosa. Gastroscopy revealed multiple polyps in the stomach and duodenum similar in appearance to F~~~ throughot..... the o....
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.005 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.006 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".