50 The Canadian Journal of CME / July 2005 CASE IN... Rheumatoid Arthritis What is RA?
Bibliographic record
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovial tissue that leads to joint destruction and long-term disability. It affects 1 % of the population and is the most common form of inflammatory arthritis. Within 20 years of onset, 90 % of RA patients have some form of disability.1 RA causes an economic burden comparable to that of coronary artery disease.2 Seventy-five per cent of the time, the onset of pol-yarthritis in RA is insidious. Usually, the small joints of the hands and feet are involved before the larger joints. At the time of presentation, many patients with RA have normal inflammatory markers. Often they are seronega-tive for rheumatoid factor and most have normal X-rays. Often, early on, RA is suspected only because of the symmetrical involvement of the small joints in the hands and feet and the absence of other conditions that imitate RA (Table 1). The cause of RA is unknown. There is no cure for the condition. Modern treatments are nonspecific, but do tar-get immune processes thought to be important in RA pathophysiology, such as tumour necrosis factor. Is it important to treat RA early? There is grade-A evidence that intervention with disease-modifying antirheumatic drugs (DMARDs) in early RA (disease duration less than one year) slows joint damage and improves the long-term outcome.3 One recent study indicates that DMARDs introduced three months into the course of RA are more effective than treatment at 12 months, with regards to joint damage and disease activity.4
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.004 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.004 | 0.004 |
| Insufficient payload (model declined to judge) | 0.136 | 0.028 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".