Probing the Structure and Luminescence of N-Heterocyclic Carbene-Stabilized Atomically Precise Metal Nanoclusters for Application in Radiati
Bibliographic record
Abstract
N-heterocyclic carbene (NHC)-protected gold nanoclusters (NCs) are stable, biocompatible, and have unique photophysical properties, making them well-suited for bioimaging, photodynamic, and radiation therapeutic applications for cancer treatment. Heterometallic NCs allow to fine-tune the core electronics and reactivity towards oxygen, which is unprecedented. However, it is not clear why particular NHC-stabilized metal NCs perform significantly better in X-ray radiation cancer treatment than others. Here we propose a detailed study of bioactive NHC-stabilized metal NCs by XAFS and XEOL to reveal the structure-properties relationship, focusing on the following three parameters that potentially affect their therapeutic efficacy: 1) metal core size, 2) sterics and electronics of NHC ligands, and 3) heteroatom doping. The knowledge obtained from this project will be essential to rationally tune the properties of NHC-stabilized metal NCs for their successful application in cancer treatment
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.013 | 0.010 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".