FastSurfer-CC: A robust, accurate, and comprehensive framework for corpus callosum morphometry
Bibliographic record
Abstract
The corpus callosum, the largest commissural structure in the human brain, is a central focus in research on aging and neurological diseases. It is also a critical target for interventions such as deep brain stimulation and serves as an important biomarker in clinical trials, including those investigating remyelination therapies. Despite extensive research on corpus callosum segmentation, few publicly available tools provide a comprehensive and automated analysis pipeline. To address this gap, we present FastSurfer-CC, an efficient and fully automated framework for corpus callosum morphometry. FastSurfer-CC automatically identifies mid-sagittal slices, segments the corpus callosum and fornix, localizes the anterior and posterior commissures to standardize head positioning, generates thickness profiles and subdivisions, and extracts eight shape metrics for statistical analysis. We demonstrate that FastSurfer-CC outperforms existing specialized tools across the individual tasks. Moreover, our method reveals statistically significant differences between Huntington's disease patients and healthy controls that are not detected by the current state-of-the-art.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.008 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.004 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.003 | 0.003 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.005 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".