The Role of Histone Demethylases in the Epigenetic Regulation of Non-Alcoholic Fatty Liver Disease.
Bibliographic record
Abstract
An ever-increasing rise in the occurrence of non-alcoholic fatty liver disease (NAFLD) presents a need to understand its development and progression with a goal of advancing novel treatment options. Epigenetics encompasses numerous modifications that mediate gene regulation amidst diverse genetic and environmental conditions. Specifically, histone methylations play a key role in the regulation of lipogenic gene expression and, like other epigenetic modifications, are inherently reversible. This presents an array of options for therapeutic intervention. This review explores the roles of specific histone demethylases and their dynamic relationships with transcription factors and target genes involved in NAFLD. I summarize how, in addition to enhancing disease progression, these histone modifications can conversely act to protect from harmful side effects of this disease. I suggest areas of future investigation into additional transcription and epigenetic factors that have yet to be studied in this context and are necessary to further our understanding of NAFLD and to develop novel treatment options.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".