Bibliographic record
Abstract
目的明确血清同型半胱氨酸(homocysteine,Hcy)水平与血管性痴呆(vascular dementia,VaD)认知功能相关性。方法收集2015年7月至2016年6月在我院神经内科门诊及住院的VaD连续病例。同时收集我院体检中心年龄、性别及受教育程度相匹配的受试者进行对照研究。采用酶循环法检测血清Hcy水平。主要应用简易精神状态检查(mini-mental state examination,MMSE)、蒙特利尔认知评估(Montreal cognitive assessment,MoCA)进行认知功能检测。结果入组VaD患者76例,健康对照组48例。VaD组平均Hcy水平约26.18±7.86μmol/L,对照组平均水平约13.63±3.40μmol/L,两组Hcy水平差异具有显著性,P=0.00(P<0.05)。正常对照组MMSE为27.96±1.81分,VaD组为13.37±3.44分,二者有明显差异,P=0.00。通过直线回归分析,我们发现VaD患者MMSE得分与血清Hcy水平有较明显的负相关,R<sup>2</sup>=0.4123。正常对照组MoCA得分为27.56±1.69分,VaD组为11.17±3.54分,二者有明显差异,P=0.00。通过直线回归分析,VaD患者MoCA与血清Hcy水平有更明显的负相关性,R2=0.5089。结论 VaD与高Hcy血症有一定的相关性,且Hcy水平越高与认知功能损伤越重。
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.011 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.005 | 0.004 |
| Open science | 0.009 | 0.004 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.117 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".