Sleep Stage-Dependent BOLD-CSF coupling in Central Disorders of Hypersomnolence
Bibliographic record
Abstract
This study investigates sleep-stage–dependent fMRI dynamics, with a focus on BOLD-CSF coupling, in healthy people and people with central disorders of hypersomnolence (narcolepsy type 1, type 2, and idiopathic hypersomnia). We aim (1) to examine how sleep stages are associated with changes in BOLD-CSF coupling and (2) to compare groups to identify potential sleep-related neural biomarkers. Data come from 97 participants across two sites (Montréal and Amsterdam) who underwent a 30-minute concurrent EEG-fMRI nap, along with questionnaires, cognitive testing, and clinical assessments. The primary outcome measure is BOLD-CSF coupling, with additional fMRI- and EEG-derived variables considered in secondary or exploratory analyses (see Variables and Analysis Plan).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.007 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.003 | 0.000 |
| Bibliometrics | 0.003 | 0.017 |
| Science and technology studies | 0.001 | 0.009 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.028 | 0.010 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.021 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".