Targeting MYB/MYBL1 gene rearrangements as diagnostic biomarkers in salivary cancers
Bibliographic record
Abstract
Lay abstract: In this study we validated MYB/MYBL1 detection using fluorescent in situ hybridization (FISH) probes for diagnosis of salivary adenoid cystic carcinoma (sACC). The study evaluated 62 patients with salivary cancer, where 49 had sACC, and 13 had non-ACC salivary cancer. FISH was used to detect MYB/MYBL1 rearrangement in patients with sACC, and DNA-based next-generation sequencing was used to confirm MYB gene rearrangement in a subgroup of 28 patients. Results showed that MYB/MYBL1 alterations were detected in 90% of sACC patients, making FISH probes a highly specific diagnostic biomarker for sACC. The study concludes that FISH probes have higher sensitivity than DNA-based NGS for detecting MYB gene fusions, making them useful for sACC diagnosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".