Evaluating Voice Biomarkers and Deep Learning for Neurodevelopmental Disorder Screening in Real-World Conditions
Bibliographic record
Abstract
Voice acoustics have been extensively investigated as potential non-invasive markers for Autism Spectrum Disorder (ASD). Although many studies report high accuracies, they typically rely on highly controlled clinical protocols that reduce linguistic variability. Their data is also recorded using specialized microphone arrays that ensure high-quality recordings. Such dependencies limit their applicability in real-world or in-home screening contexts. In this work, we explore an alternative approach designed to reflect the requirements of mobile-based applications that could assist parents in monitoring their children. We use an open-access dataset of naturalistic storytelling, extracting only the speech segments in which the child is speaking. We applied previously published ASD voice-analysis pipelines to this dataset, which yielded suboptimal performance under these less controlled conditions. We then introduce a deep learning-based method that learns discriminative representations directly from raw audio, eliminating the need for manual feature extraction while being more robust to environmental noise. This approach achieves an accuracy of up to 77% in classifying children with ASD, children with Attention Deficit Hyperactivity Disorder (ADHD), and neurotypical children. Frequency-band occlusion sensitivity analysis on the deep model revealed that ASD speech relied more heavily on the 2000–4000 Hz range, TD speech on both low (100–300 Hz) and high (4000–8000 Hz) bands, and ADHD speech on mid-frequency regions. These spectral patterns may help bring us closer to developing practical, accessible pre-screening tools for parents.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".