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Record W7116741928 · doi:10.1016/j.stem.2025.12.001

Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories

2025· article· en· W7116741928 on OpenAlexaff
Madison R. Glass, Nana Matoba, Alvaro A. Beltran, Niyanta K. Patel, Tala M. Farah, K. Kedar Eswar, S. K. Bhargava, Karen Huang, Ian Curtin, Sara Ahmed, Mary Srivastava, Emma Drake, Liam T. Davis, Meghana Yeturi, Kexin Sun, Michael I. Love, Jeremy M. Simon, Tanya. St John, Natasha Marrus, Juhi Pandey, Annette Estes, Stephen R. Dager, Robert T. Schultz, Kelly N. Botteron, Alan Evans, Sun Hyung Kim, Martin Styner, Robert C. McKinstry, D. Louis Collins, Heather E. Volk, Kelly S. Benke, Lonnie Zwaigenbaum, Heather C. Hazlett, Adriana S. Beltran, Jessica B. Girault, Mark D. Shen, Joseph Piven, Jason L. Stein

Bibliographic record

VenueCell stem cell · 2025
Typearticle
Languageen
FieldNeuroscience
TopicNeurogenesis and neuroplasticity mechanisms
Canadian institutionsUniversity of AlbertaMcGill University
FundersCenter for Environmental Health and Susceptibility, University of North Carolina at Chapel HillCancer Center, University of Florida HealthNorth Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel HillSchool of Medicine, University of North Carolina at Chapel HillEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillNational Institute of Neurological Disorders and StrokeNational Institute of Mental HealthRollins School of Public HealthUniversity of North CarolinaIntellectual and Developmental Disabilities Research CenterNational Institutes of HealthFoundation of Hope for Research and Treatment of Mental IllnessGillings School of Public HealthNorth Carolina Biotechnology Center
KeywordsInduced pluripotent stem cellOrganoidNeurogenesisMicrocephalyHuman brainPhenotypeProgenitor cellProgenitorHippocampal formation

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.248
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractno

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