Regioselective Introduction of Indolin-3-one Moieties to Substituted Heteroaromatic Compounds
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
C2-substituted indolin-3-ones are formed via a mild dual catalytic method involving the generation of a reactive C -acylimine species that can be intercepted by a variety of nucleophilic arenes. The transient C -acylimine electrophile could be trapped regioselectively by a variety of arenes, on which the most reactive site was blocked, offering a new scope of products. Competition experiments show that the C -acylimine electrophile exhibits selectivity for pyrrole over other heteroaromatic traps. Indolin-3-one functionalization of melatonin, protected amino acids, and dipeptides showcases the potential of this chemistry for late-stage diversification of biomolecules containing electron-rich arene units.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it