Clinical detection of corticobasal syndrome, beyond an “atypical" Alzheimer's
Bibliographic record
Abstract
Corticobasal syndrome (CBS) corresponds to a progressive deterioration of motor and associative cognitive functions that include ideomotor apraxia, astereognosis/loss of graphesthesia, sensory extinction, alien limb in combination with marked asymmetric limb dystonia, rigidity or myoclonus. CBS can be the initial manifestation of early-onset atypical Alzheimer's Disease (AD). Although early memory impairment has been proposed as a proxy to AD etiology of CBS, several CBS caused by corticobasal degeneration or progressive supranuclear palsy neuropathological change, do not ever develop a progressive memory impairment to the point of reaching moderate-severe dementia. In this session, we will stress the details in history taking and findings on physical examination as well as neurocognitive profile that early in the disease course help distinguish those patients with CBS of potential AD cause (CBS-ADNP).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".