Delayed Presentation of Metachronous Ascending Colonic Adenocarcinoma in Early-Onset Colorectal Cancer Undergoing Curative Resection
Bibliographic record
Abstract
Colorectal cancer (CRC) is the third most common cancer in both age groups in the world and one of the increasing causes of mortality each year. Particularly in early-onset colorectal cancer (EOCRC), this age group tends to metastasize to distant organs like the liver, lung, bone, and brain and in metachronous cases. Metachronous cancer in the colorectal adenocarcinoma is usually found in the first 2 - 3 years following curative treatment, with delayed recurrences being extremely rare. We report a rare case of a 42-year-old male with a history of ascending colon adenocarcinoma diagnosed at the age of 31. He underwent curative R0 resection with lymph node involvement, followed by 6 months of adjuvant FOLFOX chemotherapy. He remained disease-free for 11 years under routine surveillance. In 2025, he presented with symptoms of bloody diarrhea and altered bowel habits. Imaging and colonoscopic biopsy revealed a new adenocarcinoma in the distal rectum, representing a delayed metachronous. Clinical staging confirmed localized rectal cancer with limited metastasis (T3N2bM1a). Despite surgical resection being indicated, the patient declined surgery and opted for systemic chemotherapy. He tolerated treatment well, maintained functional status, and reported a good quality of life. Delayed metachronous recurrence can occur in EOCRC even after standard adjuvant therapy and prolonged remission. EOCRC also has a chance to be a delayed metachronous case. Closed follow-up should be performed, particularly in the case of those who refused the operative treatment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".