Study on the correlation between multimodal image features and multi‐cognitive domain function in patients with cognitive impairment of Qinghai plateau area
Bibliographic record
Abstract
Abstract Background Explore the imaging characteristics of brain structure and function in patients with mild cognitive impairment(MCI) and Alzheimer's disease(AD) in a high‐altitude hypoxic environment, as well as their correlation with multiple cognitive domain. Method Based on the Montreal Cognitive Assessment (MoCA) Scales, 30 elderly individuals each from the Qinghai region (average altitude: 2300 meters) with normal cognition (NC), MCI and AD were selected. There were no significant statistically differences among the three groups in terms of age, gender, and education. Multi‐cognitive domain scales were assessed. All participants underwent structural magnetic resonance imaging (sMRI) examinations. Voxel‐based morphometry (VBM) and surface‐based morphometry (SBM) methods were used. Resting‐state functional imaging techniques were analyzed brain network functional connectivity patterns. Result Compared with NC group, the volume of gray matter in left fusiform gyrus and right parahippocampal gyrus decreased in MCI group, and the volume and thickness of gray matter in bilateral entorhinal cortex and temporal pole decreased significantly in AD group ( p <0.05). orrelation analysis revealed that the gray matter volume of left fusiform gyrus was positively correlated with MoCA (r s =0.365), Auditory Verbal Learning Test(AVLT‐Delay) (r s =0.302) and Verbal Fluency Test (VFT)(r s =0.318); The gray matter volume of the right parahippocampal gyrus was positively correlated with MoCA (r s =0.355), AVLT‐Delay (r s =0.312) and Clock Drawing Test (CDT) (r s =0.363) ( p <0.01). The thickness of the right temporal pole cortex is positively correlated with MoCA scores (r s =0.363), AVLT‐delay scores (r s =0.318), VFT scores (r s =0.310), and CDT scores (r s =0.335) ( p <0.01). Moreover, compared to the NC group, the MCI and AD groups showed significant changes in ALFF, fALFF, and ReHo values in multiple brain regions ( p <0.05, GRF corrected). The sensorimotor network, ventral attention network and default mode network functional connection were significantly decreased in AD group, and the ventral attention network functional connection was significantly correlated with MoCA (r s =0.276) and CDT (r s =0.234)( p <0.05), although the strength of the correlation was weak. Conclusion During the progression from MCI to AD patients in hypoxic environments, there is a gradual deterioration in brain structure and functional connectivity, and these changes are closely related to the decline of overall cognition, episodic memory, language ability and visuospatial function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".