Association of Matrilin-1 (MATN1) and Myosin 1H (MYO1H) Polymorphisms with Mandibular Prognathism
Bibliographic record
Abstract
Background: Mandibular prognathism (Class III malocclusion) is a complex skeletal discrepancy with a strong genetic component. Recent genome-wide association studies (GWAS) and candidate gene studies have implicated Matrilin-1 (MATN1), a cartilage matrix protein, and Myosin 1H (MYO1H), a molecular motor protein, as key susceptibility markers. However, results across different ethnic populations remain inconsistent. Objective: To assess the association between specific polymorphisms in MATN1 (e.g., rs533895) and MYO1H (e.g., rs10850110) and the susceptibility to mandibular prognathism. Methods: A systematic search will be conducted using PubMed, Scopus, Web of Science, and Embase. Case-control studies comparing genotype frequencies of MATN1 and MYO1H in subjects with mandibular prognathism versus Class I controls will be included. The Newcastle-Ottawa Scale (NOS) will be used for quality assessment. If data permits, a meta-analysis will be performed to calculate pooled Odds Ratios (OR) with 95% Confidence Intervals.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.005 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.000 |
| Bibliometrics | 0.002 | 0.011 |
| Science and technology studies | 0.002 | 0.005 |
| Scholarly communication | 0.004 | 0.002 |
| Open science | 0.009 | 0.005 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.009 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".