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Record W7117529708 · doi:10.1097/cxa.0000000000000253

Using Self-report Mental Health Outcomes to Explore the Effectiveness of Inpatient Treatment for Nonmedical Opioid Use: A Retrospective Cohort Study

2025· article· en· W7117529708 on OpenAlexaffvenueabout
Emily L. Rossi, Robert Waterman, Yelena Chorny, Sarah Ahmed, Shannon Remers

Bibliographic record

VenueThe Canadian Journal of Addiction · 2025
Typearticle
Languageen
FieldMedicine
TopicOpioid Use Disorder Treatment
Canadian institutionsUniversity of GuelphHomewood Research Institute
Fundersnot available
KeywordsMental healthRetrospective cohort studyAnxietyDepression (economics)CravingChecklistOpioid use disorderCohort studyQuality of life (healthcare)

Abstract

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ABSTRACT Objective: Using within-treatment, self-reported mental health assessments for individuals receiving treatment for nonmedical opioid use at two Canadian inpatient facilities, this retrospective cohort study aimed to assess the effectiveness of this treatment. Cross-sectional demographic data were reported to determine trends and avenues for future research. Methods: Outcomes were extracted from self-report assessments completed by individuals at two private inpatient treatment facilities. Individual data were included in this study (n = 252) if they: (1) self-reported nonmedical opioid use, (2) completed admission and discharge assessments, and (3) had a planned discharge from January 2019 to December 2020. Outcomes were assessed using paired t -tests, Cohen's d, and reliable improvement ratios (where applicable) on measures of depression [Patient Health Questionnaire 9 (PHQ-9)], anxiety [Generalized Anxiety Disorder Scale 7 (GAD-7)], trauma [Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5)], substance use cravings (Aggregate Drug Craving Scale), perceived mental health (one-item rating of overall mental health), and perceived quality of life (modified Global Appraisal of Individual Needs - Q3). Results: Of individuals, 60% were males, 49% completed a college or university degree, and 76% met the criteria for opioid use disorder. Results showed significant symptom reductions from admission to discharge based on PHQ-9, GAD-7, PCL-5, and Aggregate Drug Craving Scale scores ( p < 0.0001) and significant increases in perceived mental health and quality of life scores ( p < 0.0001), with large effect sizes ( d > 0.8). Of the total, 72%, 67%, and 67% experienced a reliable improvement on the PHQ-9, GAD-7, and PCL-5, respectively. Conclusion: Our analysis presents promising outcomes for individuals treated for nonmedical opioid use in an inpatient setting. Inpatient treatment is a comprehensive approach combining medical and behavioural interventions, adjunctive therapies, and a supervised community milieu. Objectifs: À partir d'évaluations auto-déclarées de la santé mentale réalisées par des personnes durant un traitement pour usage non médical d'opioïdes dans deux établissements hospitaliers canadiens, cette étude de cohorte rétrospective visait à en évaluer l'efficacité. Des données démographiques transversales ont été consignées afin de déterminer les tendances et les pistes pour de futures recherches. Méthodes: Les résultats des évaluations auto-déclarées remplies par des personnes dans deux établissements de soins privés ont été extraits. Les données individuelles ont été incluses dans cette étude (n = 252) si elles : 1) auto-déclaraient une consommation non médicale d'opioïdes, 2) avaient rempli les évaluations d'admission et de sortie, et 3) avaient une sortie prévue entre janvier 2019 et décembre 2020. Les résultats ont été évalués à l'aide de tests t appariés, du coefficient d de Cohen et de ratios d'amélioration fiables (le cas échéant) sur des mesures de la dépression (PHQ-9), de l'anxiété (GAD-7), des traumatismes (PCL-5), des envies de consommer des substances (ADCS), de la santé mentale perçue (évaluation en un seul point de la santé mentale globale) et de la qualité de vie perçue (GAIN-Q3 modifié). Résultats: 60 % des personnes étaient des hommes. 49 % avaient obtenu un diplôme universitaire ou collégial et 76 % répondaient aux critères du trouble relié à l’usage d’opioïde (TUO). Les résultats ont montré une réduction significative des symptômes entre l'admission et la sortie, d'après les scores PHQ-9, GAD-7, PCL-5 et ADCS (p < 0,0001), ainsi qu'une augmentation significative des scores de santé mentale et de qualité de vie perçues (p < 0,0001), avec des effets de grande ampleur (d > 0,8). 72 %, 67 % et 67 % ont connu une amélioration fiable sur les échelles PHQ-9, GAD-7 et PCL-5, respectivement. Conclusions: Notre analyse présente des résultats prometteurs pour les personnes traitées pour une consommation non médicale d'opioïdes en milieu hospitalier. Le traitement hospitalier est une approche globale combinant des interventions médicales et comportementales, des thérapies d'appoint et un milieu communautaire supervisé.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.339
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2025
Admission routes3
Has abstractyes

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