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Record W7117685351 · doi:10.1136/bmjopen-2025-105188

Determinants of treatment decisions in advanced dementia: a protocol for a cross-cultural mixed-methods study

2025· article· en· W7117685351 on OpenAlexaff
João Pedro Lima, Lawrence Mbuagbaw, Manya Prasad, Amit Kumar, Guy Sadeu Wafeu, R. Bonnet, Thomas Agoritsas, Sheyu Li, Z.C. Liu, Pablo Alonso‐Coello, Fábio Akio Nishijuka, Reza Mirza, Caroline Matos Silva, Rajaa M. Alshanketi, Imtinan Alsahafi, Alanood Alnuaimi, Anja Fog Heen, Lisa Schwartz, Gordon Guyatt

Bibliographic record

VenueBMJ Open · 2025
Typearticle
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsSt. Joseph’s Healthcare HamiltonMcMaster UniversityMcGill UniversityImpact
Fundersnot available
KeywordsProtocol (science)DisseminationResearch ethicsHealth services researchInstitutional review boardPublic healthInformation DisseminationAlternative medicine

Abstract

fetched live from OpenAlex

INTRODUCTION: Values and preferences are key determinants of optimal care, and variability in patient values and preferences often dictates differences in patient management. Clinicians' views of patients' values and preferences may differ across cultural aspects and stage of training, but the extent to which this is the case remains uncertain. One key value and preference issue is the trade-off between quantity and quality of life, and this issue is particularly prominent among patients with dementia. We therefore propose to investigate the extent to which physicians' perceptions of optimal management for patients living with advanced dementia may differ due to cross-cultural factors and stage of medical training. METHODS AND ANALYSIS: We will conduct a sequential explanatory mixed-methods study (QUAN → qual). First, we will administer paper-based or electronic surveys during educational sessions, conferences and rounds to medical students, residents and physicians in ten countries, either in person or online. Following that, a qualitative inquiry, guided by the findings of the quantitative study and the principles of the interpretive description design, will inform an in-depth exploration of the predictive factors identified in the quantitative data analysis. ETHICS AND DISSEMINATION: The Hamilton Integrated Research Ethics Board at McMaster University has approved this study (approval number 2024-17651). We will disseminate our findings in peer-reviewed publications and present results at conferences as oral and poster presentations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.121
metaresearch head score (Gemma)0.092
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Qualitative · Consensus signal: none
GenreCandidate signal: Protocol · Consensus signal: Protocol
Teacher disagreement score0.121
Threshold uncertainty score0.642

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1210.092
Meta-epidemiology (narrow)0.0050.005
Meta-epidemiology (broad)0.0070.007
Bibliometrics0.0060.007
Science and technology studies0.0060.004
Scholarly communication0.0050.004
Open science0.0050.004
Research integrity0.0080.009
Insufficient payload (model declined to judge)0.0830.015

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.556
GPT teacher head0.671
Teacher spread0.114 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designQualitative
Domainnot available
GenreProtocol

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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