Secukinumab-induced ulcerative colitis in a patient with psoriasis successfully treated with risankizumab
Bibliographic record
Abstract
Interleukin (IL) 17A antagonists are increasingly used for psoriasis and other indications such as ankylosing spondylitis or hidradenitis suppurativa but can paradoxically trigger inflammatory bowel disease (IBD). We present a 51-year-old male patient with psoriatic arthritis who developed ulcerative colitis (UC) 12 months after initiating secukinumab therapy. Colonoscopy revealed continuous colonic inflammation with large ulcers in the rectum (Montreal E3). Faecal calprotectin was 87 µg/g. Secukinumab was discontinued and therapy with mesalazine was initiated. To ensure continued psoriasis control and treatment of UC, risankizumab, a selective IL-23 inhibitor, was administered at the standard psoriasis regimen. Over 12 months, the patient achieved clinical, endoscopic and histological remission. This case illustrates the dual role of IL-17A in mucosal immunity and risk of IBD induction by IL-17A blockade. Selective IL-23 inhibition may represent an effective strategy for managing IL-17A antagonist-induced UC while preserving psoriasis control.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".