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Record W7118507545 · doi:10.1093/ije/dyaf222

Impact of evolving fertility policies on maternal and neonatal outcomes in southeastern China: a 10-year population-based cohort study

2025· article· en· W7118507545 on OpenAlexaff
Yiquan Xiong, Peng Zhao, L. Thabane, Mingyu Liao, Jin Guo, Wanqiang Wei, J Chen, Y Ren, Guanhua Yao, Yongyao Qian, Biao Rong, Moliang Chen, X Sun, J Tan

Bibliographic record

VenueInternational Journal of Epidemiology · 2025
Typearticle
Languageen
FieldMedicine
TopicAssisted Reproductive Technology and Twin Pregnancy
Canadian institutionsMcMaster UniversitySt. Joseph’s Healthcare HamiltonImpact
FundersWest China Hospital, Sichuan UniversityNatural Science Foundation of Sichuan ProvinceNational Natural Science Foundation of China
KeywordsFertilityCohort studyEpidemiologyMaternal healthCohortPublic healthNeonatal mortalityPopulation

Abstract

fetched live from OpenAlex

BACKGROUND: After over three decades of the one-child policy (OCP), China introduced the partial two-child policy (PTCP) in 2013 and the universal two-child policy (UTCP) in 2015. However, their potential impacts on maternal and neonatal health remain unclear. This study aimed to examine temporal changes in maternal characteristics and neonatal outcomes across different policy periods. METHODS: We used data from a population-based pregnancy registry in Ximen, China. Maternal characteristics and neonatal outcomes were compared across the three periods: OCP (2012-2014), PTCP (2014-2016), and UTCP (2016-2021). Joinpoint regression and interrupted time series (ITS) model were applied to evaluate temporal trends and quantify the effect of policy implementation on trends over time. RESULTS: Among 491 895 pregnancies, the proportion of advanced maternal age and multiparity rose significantly after policy shifts. Maternal obesity, hypertensive disorders of pregnancy, and gestational diabetes showed steady increases. Monthly births peaked in 2016, then declined below the pre-PTCP baseline level by 2020. Compared to OCP, the prevalence of birth defects (BDs) increased by 62% during PTCP and 204% during UTCP. Preterm birth and low Apgar scores also rose. ITS indicated a significant post-UTCP acceleration in BDs (β3 = 2.57), largely driven by circulatory system BDs, with maternal age acting as a partial mediator. CONCLUSION: China's TCP implementation was associated with notable shifts in maternal risk profiles and increased adverse neonatal outcomes, underscoring the need for continuous maternal-child health monitoring during fertility policy transitions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.117
Threshold uncertainty score0.233

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.002
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.385
Teacher spread0.361 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2025
Admission routes1
Has abstractyes

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