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Record W7118641193 · doi:10.18609/cgti.2020.045

Drawing parallels and cross-pollinating ideas between viral vector and vaccine fields

2020· article· en· W7118641193 on OpenAlexaffabout
Amine Kamen

Bibliographic record

VenueCell and Gene Therapy Insights · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicViral Infectious Diseases and Gene Expression in Insects
Canadian institutionsMcGill University
Fundersnot available
KeywordsParallelsProcess (computing)Technology transferManufacturing processProcess developmentBioprocessSection (typography)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Abstract

fetched live from OpenAlex

Amine Kamen is Professor of Bioengineering at McGill University, and Canada Research Chair in Bioprocessing of Viral Vaccines. He is Researcher Emeritus of the National Research Council of Canada (NRC) where he was employed until the end of 2013, as Head of the Process Development section of the Human Health Therapeutics Portfolio. At NRC, he established one of North America’s largest and most advanced governmental centers for animal cell culture addressing process development and scale up of biologics. Along with his team he also licensed multiple technology platforms for efficient manufacturing of recombinant proteins, viral vectors, and vaccines, and led technology transfer to manufacturing sites for clinical evaluation and commercialization.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.020
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.020
Threshold uncertainty score0.105

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0200.013
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0050.003
Science and technology studies0.0040.033
Scholarly communication0.0140.034
Open science0.0030.008
Research integrity0.0060.019
Insufficient payload (model declined to judge)0.0060.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.260
Teacher spread0.246 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes2
Has abstractyes

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Same venueCell and Gene Therapy InsightsSame topicViral Infectious Diseases and Gene Expression in InsectsFrench-language works237,207