Aumento de interferom gama no aborto recorrente:uma revisão sistemática
Bibliographic record
Abstract
Embryo implantation is a high complex phenomenon involving hormonal changes in the mother, affecting immune response and the events of embryonic maturation. If such events are not synchronized there may be gestational losses. The embryo behaves in the maternal organism as a semi-allogenic graft, and is thus vulnerable to rejection and immune tolerance mechanisms. Trophoblast cells and endometrial cells synthesize one or more interferon, including IFN-γ (proinflammatory cytokine). The literature suggests that the cause of recurrent miscarriage is alloimmune rejection of the fetus. The presente study aimed tosystematically review the literature to investigate the association between IFN-γ levels and the occurrence of abortion As a methodology a systematic review was carried out on the association between interferon gamma and recurrent abortion. To analyze the quality of the studies, it was based on the Newcastle-Ottawa scale; the levels of evidence from the studies were established by the classification of degrees of recommendation proposed by the Oxford Center for Evidence-Based Medicine; and for statistical analysis, meta-analysis was used.A search was carried out in 15 databases, finding a total of 7.464 studies were searched, after following the inclusion and exclusion criteria, 48 studies were left for a detailed analysis, of which 10 articles, case controls, were eligible for this review, 4 studies inclueded for meta-analysis. In these articles, It was identified that all participants were of fertile age and also it was used as evaluation method the flow cytometry and Enzymatic Imunoadsorption Assay for interferon gamma found in the peripheral blood, decidua and endometrium. Regarding the quality of studies, all presented good quality, with moderate degree of evidence. The studies included in the meta-analysis showed high heterogeneity. However, the individual effect observed in all studies included in the meta-analysis, as well as the general effect estimate, indicated that the deciduous cells of pregnant women with a history of recurrent abortion produce significantly higher levels of IFNγ compared to the production of this cytokine in pregnant women without history of abortion. Although studies suggests an increase in IFNγ in cases of recurrent abortion further research are necessary with robust data to reinforce our results.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.029 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.005 |
| Bibliometrics | 0.011 | 0.009 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".