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Harnessing Machine Learning for Ocular Disease Detection: Performance Evaluation of Gradient Boosting Models

2025· article· W7125578346 on OpenAlexaff
Ragini Y P, Ghassan Samara, Swathi B, N E Chandra Prasad

Bibliographic record

Venuenot available
Typearticle
Language
FieldMedicine
TopicRetinal Imaging and Analysis
Canadian institutionsHorizon College and Seminary
Fundersnot available
KeywordsWorkflowGeneralizability theoryBoosting (machine learning)Robustness (evolution)Receiver operating characteristicGradient boostingMedical imagingFeature selection

Abstract

fetched live from OpenAlex

The risk of vision loss can be reduced by early diagnosis of ocular diseases and hence better patient outcomes. As the ophthalmic imaging data continues to increase, machine learning (ML) techniques are being used as effective method in elaborated disease diagnosis. The paper is dedicated to the implementation of the Gradient Boosting Models (GBMs) to the accurate discrimination and detection of different ocular diseases according to the fundus images features and patient metadata. The dataset which contained clinical characteristics like the age, sex, fundus images of both the eyes and related diagnostic keywords were examined. Data pre-processing and feature engineering have been performed to maximize the quality of data and derive the patterns of interest. Stratified k-fold cross-validation was used to provide robustness as well as avoiding over fitting using the GBM algorithm. The most important parameters by which the performance of the models was tested consisted of accuracy, precision, recall, Fl-score, and the area under the receiver operating characteristic curve (AUC-ROC). Findings indicate that GBMs have good diagnostic precision and generalizability rates concerning various ocular disorders. The present study presents the opportunity offered by ensemble learning, GBM in particular, to help ophthalmologists by giving them automated, trusted diagnostic support. The results can support applying ML models with interpretable behaviour to the clinical workflow to ensure the early diagnosis and treatment strategy in ophthalmology.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.551
Threshold uncertainty score0.930

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.324
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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