Hypertrophic cardiomyopathy: From accidental diagnosis to sudden cardiac death prevention
Bibliographic record
Abstract
Hypertrophic cardiomyopathy is defined by the presence of increased thickness of the left ventricular wall, which cannot be explained only by abnormal loading conditions. This definition applies to children and adults and makes no "a priori "assumptions about etiology or myocardial pathology. Cellular architecture disorders, interstitial fibrosis, microvascular infarctions, play a role in the emergence of electrical instability, malignant ventricular arrhythmias that cause Sudden Cardiac Death in patients with HCM. Although most cases have a benign prognosis, identifying patients at a risk for Sudden Cardiac Death, requiring prophylactic therapy with ICD, is crucial and prioritized. With increasing awareness of the disease, lower-risk patients are now more frequently diagnosed, and more recent studies show that the annual Sudden Cardiac Death rate 0.5-1%, was not negligible, unfortunately among young and asymptomatic individuals. This paper presents a case of HCM, accidentally detected in a young adult, completed with ICD implantation in primary Sudden Cardiac Death prevention.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".