Actomyosin cortex integration with complex plasma membrane topography in the early <i>Drosophila</i> embryo
Bibliographic record
Abstract
Most animal cells display widespread plasma membrane (PM) folding. It is unclear how cortical tension is generated and controlled over cell surfaces with such PM topography. Our results highlight the early syncytial Drosophila embryo as a model of cortical actomyosin network integration with complex PM topography. Over the embryo surface, before arrival of peripheral nuclei, actomyosin networks entwine across a dense field of PM infoldings. Actomyosin network and PM topography changes are closely coupled during synchronous mitotic cycles and following experimental perturbations. Actomyosin activity is required for periods of condensed spacing between PM infoldings, when the integration of actomyosin networks and PM topography seems to form a tensile, composite material. These cyclic condensations are preceded by periods of expanded spacing between PM infoldings driven by Arp2/3 activity. Without Arp2/3 activity, the actomyosin cortex and PM topography gain an aberrant configuration, excessive tension is evident, and embryo surface distortions occur. Overall, PM topography seems integral to actomyosin cortex function and regulation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".