Bibliographic record
Abstract
A seven-year-old male castrated Labrador Retriever was referred to the Cornell University Hospital for Animals (CUHA) for a two-week history of anterior uveitis in the left eye and a four-five month history of hemorrhagic large bowel diarrhea. Refractory clinical signs and exhaustion of non-invasive diagnostics prompted referral for an upper and lower GI endoscopy performed on 4/14/15 at the Veterinary Medical Center in Syracuse. Biopsy results and fungal serology were sent to Texas A&M College of Veterinary Medicine. Results were pending at the time of presentation. On presentation to the CUHA Ophthalmology service, the dog was bright, alert and responsive. Ophthalmic exam revealed absent direct pupillary light reflex OS (left eye), absent menace OS, and 3+ flare of the anterior chamber. The intraocular pressures were 10 OD (right eye) and 35 OS (mmHg). The fundus displayed chorioretinitis with multifocal areas of subretinal hemorrhage and retinal edema OD and complete bullous retinal detachment with intraretinal white lesions OS. The dog had a left sided head tilt and mild kyphosis of the thoracolumbar spine. The remainder of the physical exam was unremarkable. These ophthalmic findings, coupled with the left sided head tilt and several month history of refractory colitis, were suggestive of protothecosis. Additional diagnostics including urine culture, cytology of subretinal aspirates, and culture of the subretinal aspirate were performed. All tests confirmed presence of P?rototheca s?pp. The dog was hospitalized and treatment with amphotericin B and itraconazole was initiated. Intravenous fluid therapy was utilized to mitigate nephrotoxicity secondary to amphotericin administration. The dog was maintained on antibiotics (metronidazole and doxycycline), antacids and antiemetics and ocular medications. The patient?s condition remained relatively static over 5 days of hospitalization with some improvement with respect to hematochezia. He was discharged on 4/27/15 to the care of his owner. The patient continued to receive amphotericin therapy with his primary veterinarian. Over the course of several days, the patient became blind in both eyes. Due to the lack of response to medical management and the grave prognosis associated with this disease, euthanasia was elected. This report will describe the pertinent clinical findings, diagnostics and treatment in a dog with disseminated protothecosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".