MétaCan
Menu
Back to cohort
Record W7127224739

Insulin : the modern era

2025· article· en· W7127224739 on OpenAlexaboutno aff
Maria Mizzi, Simon Mifsud

Bibliographic record

VenueOAR@UM (University of Malta) · 2025
Typearticle
Languageen
FieldMedicine
TopicDiabetes Management and Research
Canadian institutionsnot available
Fundersnot available
KeywordsInsulinDiabetes mellitusInsulin pumpHormoneType 2 diabetesType 1 diabetesPancreatic hormone
DOInot available

Abstract

fetched live from OpenAlex

Insulin – a naturally occurring hormone produced by beta cells in the pancreas, has been successfully isolated and purified in the year 1921 by the scientists Banting and Best in Toronto. Since then, more than 100 years later, different formulations and delivery methods have been developed. Type 1 diabetes depends on insulin for survival and reduced morbidity. Therefore, it came naturally with time to research newer technologies that mimic as much as possible the job of the pancreatic beta cells to provide insulin. This led to the development of the first model of continuous subcutaneous insulin infusion in the 1970s. Several advantages have been linked to the insulin pump as opposed to multiple daily insulin injections. Literature mentions better glycaemic outcomes with increased time in range and reduced hypoglycaemic episodes with insulin pumps. Other benefits vary from practical and psychological benefits with regards to the changing mentality towards living with type 1 diabetes, to long-term benefits involving the reduction of micro- and macrovascular complications. Studies are still being conducted to determine whether type 2 diabetic patients could also benefit from such insulin pumps.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.800
Threshold uncertainty score0.471

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.234
Teacher spread0.222 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designOther design
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueOAR@UM (University of Malta)Same topicDiabetes Management and ResearchFrench-language works237,207