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Decoding Drift: Trustworthy Prompt Optimization in High-Stakes AI Environments

2025· article· W7130594573 on OpenAlexaff
Gokul Narain Natarajan, Sarbani Paul, Jyoti Kunal Shah, Ankur Tiwari, Ramesh Bellamkonda

Bibliographic record

Venuenot available
Typearticle
Language
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsOccupational Cancer Research Centre
Fundersnot available
KeywordsInterpretabilityTrustworthinessReliability (semiconductor)Benchmark (surveying)Baseline (sea)CalibrationReinforcement learning

Abstract

fetched live from OpenAlex

The reliability and trustworthiness of Large Language Models (LLMs) take shape as more high-stake industries like healthcare, finance, and legal systems embrace them as their applications. Nonetheless, the issue of prompt drift (minor cumulative deviations in the model behaviour because of differences in the prompt structure and contextual framing) is a major threat to model outputs that are consistent. We have introduced a sound solution to the trustworthy prompt optimization (TPO) problem in the form of a systematic and comprehensive methodology that mitigates the drift issue in three major ways: (1) a drift-sensitive evaluation criterion measuring semantic and policy deviation in the responses of LLCs through LLPitals, (2) a prompt tuning algorithm that balances performance and interpretability based on reinforcement learning, and (3) a module that allows the calibration of a human in the loop in high-stakes decision situations. The outcomes of experiments in three benchmark datasets of clinically relevant, fraud detection and legalistic reasoning tasks show that the proposed TPO framework is up to 27 percent more stable in output and 19 percent more faithful to the facts compared to the competing prompt engineering baselines. This study preconditions ethically sound and reproducible prompt design in safety-sensitive AI products, providing a template of compliance of regulations and ethical assurance within the framework of LLM implementation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.018
metaresearch head score (Gemma)0.110
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.018
Threshold uncertainty score0.096

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0180.110
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0010.003
Scholarly communication0.0030.005
Open science0.0020.005
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.067
GPT teacher head0.391
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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