Expression and localization of iNOS, BCL-2 and MMP-9 in the synovial sheath of the hip in patients with osteoarthritis
Bibliographic record
Abstract
Osteoartritis kuka (OAK) je karakteriziran razgradnjom hrskavice i sinovitisom zgloba kuka. Međutim, patohistološki učinci upale sinovijalne ovojnice na OAK nisu jasni. Cilj ove studije bio je ustanoviti izražaj iNOS, BCL-2 i MMP-9 u različitim tipovim stanicama sinovijalne ovojnice. Retrospektivno smo analizirali 32 bolesnika. Dokumentirali smo dob, spol, tjelesnu težinu i visinu, indeks tjelesne mase ta analizirali sinoviocite slične fibroblastima, makrofage i limfocite u rezovima tkiva. Stupnjevali smo OAK uz pomoć OARSI (engl. osteoarthritis cartilage histopathology assessment system) zbroja, WOMAC (engl. Western Ontario and McMaster Universities Osteoarthritis Index) i HHS (engl. Harris Hip Score) zbroja, zbroja po Krennu i K-L (engl. Kellgren-Lawrence) zbroja. Operacija potpune aloartroplastike kuka napravljena je u 32 bolesnika, uključujuči kontrolnu skupinu. Bolesnike smo podijelili u dvije skupine obzirom na izraženost bolesti. Tkiva smo analizirali imunohistokemijskim metodama. Postoji razlika u zbroju po Krennu i K-L zbroju između sve tri skupine, ali i između skupina umjerenog i izraženog oblika OAK. Broj slojeva epitela, rezidentnih stanica strome i posebno limfocitni infiltrat se povećavaju sukladno izraženosti OAK. Izražaj iNOS, u intimi i subintimi pozitivno korelira sa zbrojem po Krennu u skupinama s umjerenim i izraženim OAK. Izražaj BCL-2 u intimi u skupini izraženog OAK pozitivno je povezan sa zbrojem po Krennu. Zaključno, iNOS, BCL-2 i MMP-9 su uključeni u regulaciju OAK. Ova studija ukazuje na povezanost patohistoloških značajki, upale sinovijalne ovojnice i stanja hrskavice zgloba kuka u bolesnika operiranih zahvatom ugradnje potpune aloartroplastike zgloba kuka zbog OA ili prijeloma.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".