Bibliographic record
Abstract
Telomeres are the physical ends of linear chromosomes and have an important role in protection of genomic integrity. Telomeres can be elongated by a unique ribonucleoprotein enzyme called telomerase. Telomere length maintenance is implicated in aging as well as the human diseases cancer and dyskeratosis congenita. In yeast, Est1p is known to co-mediate telomerase access and is essential for telomere length maintenance in vivo. This study characterizes a murine homologue of Est1, mEst1A. Murine embryonic stem cells with one disrupted mEst1A allele were generated, but viable null lines were not, suggesting possible lethality in the homozygous state. mEst1A mRNA was detected in most tissues examined, but not protein, perhaps due to low expression levels or inadequate antibodies. Immunoprecipitation analysis revealed an in vitro interaction of HA-tagged mEst1A with telomerase activity. These studies provide a valuable system with which to study further the role of Est1A in mammalian telomere length homeostasis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".