The effects of insulin-like growth factor binding protein-1 on pre- and postnatal cardiac morphology and function
Bibliographic record
Abstract
Insulin-like growth factors (IGFs) are essential regulators of fetal growth. Their effects are modulated by the IGF binding proteins (IGFBPs). Circulating IGFBP-1 levels are elevated in growth-restricted human fetuses, and fetal growth restriction increases the risk of cardiovascular diseases in adulthood. Transgenic mice with elevated levels of circulating IGFBP-1 in late gestation were shown to be growth restricted, and have improved overall left and right ventricular function, eccentric left ventricular hypertrophy, cardiomyocyte hypertrophy, and decreased cardiomyocyte proliferation at E17.5. Postnatally, transgenic mice did not exhibit catch-up growth and showed left ventricular overall, diastolic, and systolic functional impairments, and wall thinning in adulthood ( ge;8 week). We conclude that growth restriction caused by elevated IGFBP-1 alters pre- and postnatal cardiac structure and function and this may increase the risk of cardiovascular disease in adulthood.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".