Bibliographic record
Abstract
Bipolar Disorder (BD) is a chronic mental disorder characterised by episodes of hypomanic/manic, depressed, or mixed mood. Monoamine oxidase B (MAO-B) is an enzyme that is associated with oxidative stress in the brain and is found in astrocytes, a type of glial cell. Reports suggest neuroinflammation in BD may be associated with astrocyte dysfunction. The aim of this pilot positron emission tomography (PET) study was to evaluate MAO-B volume distribution (VT) as an index of astrocyte activity in the prefrontal cortex, and anterior cingulate cortex of adults with BD depression using the radiotracer, [11C]SL2511.88. Recruitment was conducted at the Centre for Addiction and Mental Health (CAMH), Toronto from January 2021 and is ongoing. Findings indicated reduced MAO-B VT in participants with BD depression (n=4) compared to healthy controls (n=20), suggesting astrocyte loss/dysfunction. Further investigations are required to confirm whether reduced MAO-B VT is associated with the neuropathology of BD depression.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".