Early Detection of Polyneuropathy in Patients with Hereditary Transthyretin Amyloid Cardiomyopathy and Determining the Cost-Effective Treatment for Mixed Phenotype Patients
Bibliographic record
Abstract
Transthyretin amyloidosis is a rare disease caused by the deposits of misfolded proteins known as amyloid. This disease is caused by misfolded transthyretin (TTR) proteins, that are produced in the liver and are deposited in various organs and tissues, especially in the heart and nerves. These TTR proteins are normally formed as stable tetramers; however, a mutation on the TTR gene could cause the dissociation of the TTR tetramer into monomers which would then form as TTR amyloid causing transthyretin amyloidosis (ATTR). Patients with ATTR may present cardiomyopathy and/or polyneuropathy. Although there is no cure for this disease, there are treatments available that would slow down the progression of ATTR and allow patients to have a better quality of life (QOL). The treatments include organ transplantation (liver/heart) or novel disease modifying therapies. This thesis focuses on detecting polyneuropathy among patients with hereditary transthyretin amyloid cardiomyopathy and determining its cost-effective treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".