Investigating the Endocannabinoid System in Major Depressive Episodes: Imaging with the Radiotracer [11C]CURB
Bibliographic record
Abstract
Purpose. To determine whether brain fatty acid amide hydrolase (FAAH) is elevated in vivo in patients with major depressive episodes (MDE) and if FAAH is related to depressive severity.Methods. Medication-free MDE and healthy control (HC) participants were recruited. All participants were administered the Structured Clinical Interview for DSM-5 and Hamilton Depression Rating Scale. FAAH was measured using [11C]CURB positron emission tomography. Results. Seven MDE and 10 age- and sex-matched HC participants completed the study. Data showed no significant group differences in FAAH, and no correlation between FAAH and depressive severity in MDE. FAAH in the medial prefrontal cortex, amygdala, ventral striatum, and substantia nigra were positively correlated with apathy in MDE. It should be noted that this study was underpowered. Conclusion. This study is the first to investigate FAAH in MDE in vivo. Despite no significant group differences in FAAH levels, FAAH may be related to apathy in MDE.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".