Construction of Snthetic Elastomer Lung Scaffolds with Human iPSC-derived Lung Organoids
Bibliographic record
Abstract
Introduction: With the only treatment option for chronic respiratory diseases being lung transplantation, a high-risk procedure, there is an urgent requirement for a curative solution. The synthetic polymer, poly(itaconate-co-citrate co-octanediol) (PICO) with tunable elasticity, tensile strength, and a controllable degradation rate may aid in the growth of lung cells. Methods: 2D and 3D scaffold models were seeded with human induced pluripotent stem cells (iPSC) derived lung organoid (LO) cells and evaluated for cell attachment, viability, proliferation, and morphology. ECM proteins were selected and evaluated for their ability to enhance attachment and proliferation of LO cells. Results: PICO scaffold demonstrates to support the attachment, viability, proliferation, and morphology of LO-dissociated cells in both the 2D and 3D scaffold model. Some of the ECM protein supplements may aid in the attachment and proliferation of LO cells. Conclusions: PICO, as demonstrated in-vitro, can be a useful tissue engineering tool for repairing the lung.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".