Craniofacial effects of alendronate treatment in growing osteogenesis imperfecta mice
Bibliographic record
Abstract
Bisphosphonates have shown promise in reducing fractures in children with osteogenesis imperfecta (OI). To date, effects of these drugs on the growing craniofacial skeleton have not been investigated. To address this, alendronate (ALN) was evaluated in the growing oim/oim mouse, a model of moderate-to-severe OI. Wildtype (+/+) and oim/oim mice received saline or ALN at a dosage of 26 μg ALN/kg/day from 6-12 weeks of age. Skulls (n=49) were scanned at 12 weeks with microCT to create 3D reconstructions. Cranial and mandibular landmarks were digitized and statistical shape analysis methods compared cranial and mandibular size and shape between groups. Back-scattered electron imaging of the spheno-occipital synchondrosis evaluated drug effects on bone quality. oim/oim mice exhibited significant skull dysmorphology with parallels to human OI. The anti-resorptive activity of ALN does not appear to compromise craniofacial growth. ALN treatment normalized FM morphology in oim/oim mice through improvements in skull bone quality.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".