Bibliographic record
Abstract
Self-renewal is the ability of a cell to produce identical daughter cells upon division. Multipotent hematopoietic stem cells (HSCs) permanently self-renew whereas more differentiated cells have only transient self-renewal capacities or none at all. Despite the importance of self- renewal in sustaining blood cell populations, the molecular mechanisms that regulate it is unclear. Hoxb4, a member of the Homeobox family of transcription factors, has been implicated in self-renewal regulation due to evidence suggesting that exogenous HOXB4 seems to sustain the self-renewal capacity of oligopotent progenitors (OPPs). However, the specific cells susceptible to this immortalization remains unknown. The purpose of my thesis is to identify these cells so that they can be purified and analyzed which will uncover the regulatory underpinnings of self- renewal. I have identified a potential cell population that exhibits permanent self-renewal given HOXB4. These cells are not as primitive as multipotent HSCs nor as differentiated as certain OPP subsets.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".