Lithium protects the rodent amygdala from neuronal and molecular effects of chronic stress
Bibliographic record
Abstract
Bipolar disorder (BD) is a debilitating psychiatric illness, yet its etiology remains poorly understood. Stress contributes to the emergence and recurrence of BD, therefore neuronal and molecular actions of the mood-stabilizing drug lithium were investigated using a chronic restraint stress (CRS) paradigm in rodents. Based on previous findings, it was hypothesized that lithium would protect the rat amygdala against stress-induced dendritic hypertrophy, as well as decreased levels of phosphorylated CREB (pCREB) protein and brain-derived neurotrophic factor (BDNF) mRNA transcripts. As expected, lithium treatment prevented CRS-induced dendritic hypertrophy, and reversed a decrease in the number of pCREB-positive cells and density of pCREB-induced BDNF mRNA transcripts in the basolateral and lateral amygdala. The results of this thesis support the neuroprotection hypothesis of lithium action, and suggest that CRS is a useful model within which to study the effects of lithium on changes in neuroplasticity relevant to BD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".