Effect of dopamine depletion on D1 receptor binding in rat brain ; and metabolism studies of D1 agonist R-[11C]KF 82957 and phosphodiesterase-4 inhibitor R-[11C}rolipram
Bibliographic record
Abstract
In theory, contrary to DA D1 antagonist SCH 23390, D 1 agonist SKF 82957 is expected to bind selectively to D1 HIGH in vivo. Phosphodiesterase-4 (PDE4) plays a role in controlling cAMP levels, disturbances of which have been linked to depression. The objectives of this project are to utilize R-[ 11C]SKF 82957 and [11C]SCH 23390 to assess changes in D1 receptors, and determine the levels of unchanged PDE4 inhibitor R-[11C]rolipram after treatments reducing endogenous DA, and affecting cAMP levels, respectively. We hypothesized that the proportion of D1HIGH will increase following DA depletion, with no production of metabolites, and that unchanged R-[ 11C]rolipram plasma levels will remain unchanged following drug treatment. Results suggest that only AMPT is able to increase the proportion of D 1HIGH, although a metabolite is detected in rat brain. Levels of unchanged R-[11C]rolipram are significantly affected by maprotiline and thioperamide, although a general upward trend is visible for several other drugs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".