Development of Calcium Alginate Hydrogels for the Ionically Triggered Release of an Ophthalmic Wetting Agent
Bibliographic record
Abstract
This thesis investigates the feasibility of using calcium alginate beads for wetting agent delivery by assessing their encapsulation efficiency (EE), payload retention and release profiles. Beads formulated with the addition of 7.5 mM PEG (10 kDa) or PVP (10 kDa) in the gelation bath showed an increase in EE and payload retention. The properties of the viscosity-modifying polymer layers on calcium alginate beads affected the in vitro release of encapsulated model drug Rhodamine B-Dextran (70 kDa) into simulated tear fluid, enabling modulation of release rates. Meanwhile, storage in high viscosity media such as 50% (v/v) glycerol solution allowed for lower passive release and storing in 450 mM calcium chloride solution led to almost a zero-order release. These results indicate that fine-tuning the cross-linked alginate beads’ formulation and storage condition can produce controlled, ionically triggered drug release.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".