Bibliographic record
Abstract
Estrogen plays a major role in breast cancer development and progression making those enzymes involved in its metabolism and synthesis, both systemically and locally, targets for breast cancer treatment and prevention. Flaxseed and soy are major dietary sources of phytoestrogens, lignans and isoflavones respectively. In postmenopausal women flaxseed, but not soy, altered the metabolism of estrogen as indicated by the urinary excretion of 2- and 16α-hydroxyestrone. Flaxseed shifted the metabolism of estrogen to the less biologically active estrogen, 2-hydroxyestrone. In vitro, the effect of purified lignans (enterolactone, enterodiol) and isoflavones (genistein) on estrogen synthesis were examined in MCF-7 cells. Enterolactone, enterodiol and genistein significantly decreased the amount of estrogen produced by aromatase and enterolactone and genistein by 17β-HSD type 1, key enzymes involved in estrogen synthesis. Changes in enzyme activity were significantly related to changes in cell proliferation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".