The Structural and Functional Connectivity of the Cerebellum in Autism Spectrum Disorder
Bibliographic record
Abstract
The cerebellum coordinates motor, cognitive, and affective function in the brain, largely via its connectivity to the cerebral cortex. Perinatal injury to the cerebellum and mutations to genes integral for cerebellar development are strongly associated with Autism Spectrum Disorder (ASD), a highly prevalent neurodevelopmental disorder with an unclear etiology and heterogeneous behaviour presentation. Disrupted cerebellar development results in changes to its coordinated growth and neurophysiological activity with other brain regions, heretofore referred to as structural and functional connectivity. Recurrent patterns in cerebellar-cerebral connectivity in the context of atypical neurodevelopment have been observed. However, much is still unknown regarding the extent to which these patterns correspond to particular ASD-related behaviours and genetic mutations. In chapter 2, behaviour-correlated functional connectivity profiles - measured using resting-state functional magnetic resonance imaging (MRI) - were identified using a neurodevelopmental disorder (NDD) imaging and behaviour dataset. The findings were then assessed for replication using an independent dataset from a second consortium. Two functional connectivity components were observed in the original and replication dataset: a first component maximally correlated to obsessive-compulsive behaviour and a second component characterized by social communication deficit contrasted against attention deficit. Statistically stable features of these components mainly included nodes pertaining to the attentional, central executive, and default mode networks. Having identified functional connectivity profiles correlated to ASD-related behaviours, structural connectivity profiles were then characterized and compared to those of clustered mouse models, where each model bore a genetic mutation associated with ASD. Structural connectivity was defined as correlations between regional brain volumes measured via MRI. Two mouse model clusters were significantly similar to human clusters following False Discovery Rate correction: the cluster with elevated protein product expression in the cerebellum versus the cerebrum, and the cluster with genes implicated mTOR pathway biomolecule synthesis. Structural correlations were most similar between mice and humans for correlations between cerebellar Crus II or vermal lobule VI and all cerebral regions. Similar to the findings of chapter 2, large structural correlation differences mainly involved regions pertaining to the attentional, central executive, and default-mode networks.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".