Bibliographic record
Abstract
Atypical Rhabdoid Teratoid Tumours (ATRTs) are malignant embryonal brain tumours, of which the ATRT-MYC subgroup are particularly invasive and treatment-resistant with poor clinical outcomes. The purpose of this study is to investigate the cellular effects of the multi-tyrosine kinase inhibitor Dasatinib on ATRT-MYC tumours in vitro, as well as identify and characterize drug compounds that act synergistically with Dasatinib. Here I show that Dasatinib has a cytostatic, but not cytotoxic effect at IC50 concentrations. Proliferative impairment observed is most consistent with senescence and G1/S cell cycle arrest. Vorinostat, a histone deacetylase inhibitor, was found to act synergistically with Dasatinib at near-IC50 doses; combination showed cytostatic effects, with increased senescence markers and impaired cell cycle progression. In conclusion, while Dasatinib and Vorinostat combination did not elicit cell death, it effectively suppressed ATRT-MYC proliferation. Further study of Dasatinib-Vorinostat combination is warranted in vivo as a potential therapy for this highly lethal disease.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".