Molecular genetic investigation of brain-derived neurotrophic factor in childhood-onset mood disorder
Bibliographic record
Abstract
Childhood-onset mood disorder (COMD) is a condition with pronounced morbidity. Brain-derived neurotrophic factor (BDNF) has antidepressant-like effects at cellular and molecular levels in animals; variants of the BDNF gene have been associated with bipolar disorder. Two BDNF polymorphisms, a dinucleotide repeat, (GT)n, and a single nucleotide polymorphism (SNP), Val66 Met, were genotyped in 99 adults with COMD and matched controls. The BDNF (GT)n marker was associated with COMD (168 bp OR = 3.94, CI = 1.72 to 9.04). Alleles of Va166Met were not associated with COMD. The haplotype val/short contributes to risk. Studies in several species have implicated BDNF and catechol-O-methyltransferase (COMT) in memory. In 63 young adults with a history of COMD, we genotyped three BDNF polymorphisms and the COMT Val108/158 Met SNP. Multivariate analysis of variance (MANOVA) was employed to test hypotheses of association. We found no evidence of association between the two loci and declarative memory phenotypes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".