Investigating the Role of Integrins in Spondyloarthritis Using the SKG Mouse Model
Bibliographic record
Abstract
Spondyloarthritis (SpA) describes a group of diseases characterized by chronic inflammation in the spine and joints. Gut-derived immune cells have been identified in the joints of SpA patients and entry of these cells into joints may be mediated by integrins which bind to specific ligands expressed by both gut and joint endothelial cells. Using the curdlan-treated SKG mouse model, the role of integrins in SpA was investigated. Starting at selected time points, curdlan-treated mice were injected with anti-α4β7 or anti-β7 antibodies twice a week until endpoint. Mice treated with integrin blockade showed decreased disease severity, with greater benefit observed in mice treated with anti-β7 antibodies. Disease scores were comparable between treatment initiation times. Integrin blocking therapies have proved to be effective in inflammatory bowel disease. While this approach has not been studied in arthritis to date, my findings indicate that integrin-blocking strategies may have unrecognized therapeutic potential in SpA.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".