Development and physicochemical characterization of solid molecular dispersions of poorly water-soluble drugs in poly(2-hydroxyethyl methacrylate) hydrogels
Bibliographic record
Abstract
The purpose of this study was to characterize physicochemical parameters affecting the physical state of solid molecular dispersions of poorly water-soluble drugs in PHEMA hydrogels. Samples were prepared by an equilibrium solvent loading process and characterized by XRD, DSC and FTIR. The results confirm the existence of a threshold drug loading level above which a transition from amorphous to crystalline state may occur in the solid molecular dispersion. The onset of such change is accelerated at higher relative humidity levels during storage. The presence of hydrogen bonding between the polymer and the drug, as confirmed by FTIR, together with the glassiness of the polymer helps to retard crystallization below the loading threshold. An enhancement in dissolution rate is observed from such solid molecular dispersions. This study suggests that solid molecular dispersions based on PHEMA hydrogels can effectively enhance the apparent solubility and dissolution rate of poorly-water soluble drugs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".